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Belzutifan is often a CYP2C19 substrate. Coadministration with CYP2C19 inhibitors may well raise incidence or severity of adverse effects. Monitor for anemia and hypoxia and reduce belzutifan dose as advised.No distinct dose adjustment advised when tofacitinib coadministered with potent CYP2C19 inhibitors; reduce tofacitinib dose if coadministered